Menopause & Mood Disturbance: It Sux

"The interaction between these hormonal changes, the subsequent onset of menopause-related clinical symptoms, and the emergence of mood symptoms and cognitive deficits constitute a complex puzzle."

No kidding.

"The mechanism by which neuroregulatory changes modulate the transition to menopause is still largely unknown (Wise et al., 1996)."

Why?

Conclusion of the piece is that they don't have a clue.

Sheesh.